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Spider-Man faces a life-changing event that will give a whole new experience to everything he once knew as Spider-Man.
Peter has started to dream strange visions about his life as Spider-Man involving Uncle Ben, Morlun, Kraven and spider imagery, all of this after Tony Stark revealed to him that he's been acting strangely lately (suffering dizzy spots, losing his powers momentarely, etc.)
After facing off a criminal named Tracer, Spider-Man suffers a severe bullet injury. After being nursed to health and approve for a blood analysis by the doctor, Peter discovers that he's suffering a rare disease and has very short time to live. Unknown to him, he's being followed by Morlun, waiting for the time to attack him.
Spider-Man confronts his wife Mary Jane to tell her about his situation, but when he decides to tell his Aunt May, he ends up fighting against Tracer once again, this time defeating him and revealing him as a machine.
Spidey decides to web swing to release his stress but ends up being caught up by Morlun who proceeds to attack him and beat him but lets him go after he finds out of Peter's condition. Spidey leaves in defeat but on the way back he finds and severley beats Ox (seeing him as Moruln) only to be stopped by Daredevil from giving the thug further damage.
The following day Spider-Man receives another assault from Morlun, this time more severe than the previous one. Spidey gains the upper hand momentarily only to be savagely and severely beaten by Morlun (to the point of plcuking one of his eyes and eat it and leave him in a major bloody mess). The NYPD and medics arrive to take him to the hospital while Morlun flees the scene to wait for the right time to finish the job. The New Avengers and Mary Jane arrive to the hospital only to watch Morlun attempting to kill Peter. MJ defends Peter only to be attacked by Morlun, prompting Peter to gain one last measure of strenght to morph into a Spider-like creature with razor sharp teeth and stingers coming ot of his wrists to assault and kill Morlun. With his last breath he gives MJ his final words and farewell while Iron Man takes away his body so his death won't go public.
While discussing how to deal with the death of Spider-Man and the dissapearance of Peter Parker, strange noises come from the tower. By the time the Avengers find out, all that's left is Peter Parker's dead skin.
Peter ended up inside a cocoon underneath the Brookyln Bridge. Inside he had a vision about a spider-like entity that informed him that all these years he had been neglecting his spider-side. It was his spider-side who saved Peter's life in the battle against Morlun, but in order to return to life he must embrace his "Other" side. Peter accepts the deal and re-emerges revitalized.
After dealing with the medical tests, revealing that his evolution healed Peter of all his injuries and diseases from years past, he finds his dead skin now filled with tiny spiders, facing off a mysterious entity who came to claim Peter's life but fails to do so.
Afterwards, he goes to save the lifes of several citizens, discovering new powers (like night vision, his sedative stingers, etc.) and finds out that his evolution came after he embraced his "Other" side finally.