When Cerebra detected the sudden appearance of six hundred new mutant signatures in Tokyo, Storm sent Colossus and the team of young mutants he trained - composed of Anole, Ernst, Glob, and No-Girl - to investigate it.
Cerebra took them to the warehouse where all the mutant signatures were coming from, and for their surprise, it served as the base of the Sugar Man, an old enemy of the X-Men. Sugar Man had genetically engineered six hundred mutant embryos in total isolation from the Terrigen Mists and planned to send them to the future, where they would be safe from the M-Pox caused by the Mists and would grow to become the next generation of mutants, with Sugar Man as their leader. However, Colossus' interference separated Sugar Man from his ark and Colossus, along with his team, ended up being teleported with the embryos to the future. Soon afterwards, the X-Men arrived and, upon discovering what had happened, used Cerebra to track and follow Colossus and his team through the timestream.
Arriving a thousand years into Earth's future, the X-Men found themselves in a destroyed New York City. The X-Men soon found Colossus' team, albeit without Colossus and somewhat different as they had arrived some time before the X-Men. They were protecting the ark containing the mutant embryos engineered by Sugar Man. When they asked what had happened to Colossus, Cerebra warned them of the incoming threat: Colossus and the Horsemen of Apocalypse.
Searching for answers about the place they were, Jean Grey read the young X-Men's minds and discovered they had been there for a year, fighting their way through the bubble worlds of the Omega World, a world where the mutants no longer existed, having been wiped out along with many other races in the wake of Apocalypse, who now reigned supreme over what remained of Earth. After Jean showed what she had discovered to her teammates, the X-Men engaged the Horsemen of Apocalypse in battle.
After many failed attempts to connect with the mind of Warren Worthington (who had misteriously become Archangel again, albeit mindless) in order to discover what had happened to him, Psylocke was about to give up when she suddenly found herself inside Warren's mind. There, Warren changed back to his Angel persona and warned Psylocke about the incoming catastrophe that would befall the town of Green Ridge, and later the world if he was not stopped. Psylocke sought Magneto's help to investigate the small town of Green Ridge, in Colorado.
Meanwhile, Sabretooth and M were on a mission to meet an informant who had intel about a threat against mutantkind in New York City. As the informant didn't appear, Sabretooth followed their scent into the sewers. The informant revealed herself to be Callisto, who was hell-bent in getting revenge on Sabretooth for having killed many Morlocks in the past. After a brief fight, Callisto agreed to not attack Sabretooth again for the meantime and told M the reason she had contacted the X-Men for their help: the Morlocks were dying again.
In Green Ridge, Magneto and Psylocke suspected something was wrong with the town as she was unable to probe into its citizens minds, and followed them to a tent in the middle of the park. There, a priest welcomed everyone and introduced them to their savior, who to both Psylocke and Magneto's surprise was a wingless Warren Worthington, who now saw Mutants as aberrations.
After reading Warren's mind with his consentiment, Psylocke discovered he wasn't Warren at all and followed him to a secret vault where they were attacked and eventually subdued by Genocide and the other members of the Clan Akkaba. Beneath New York City, Callisto led Sabretooth and M to the underground hideout of the Morlocks, who were now coexisting in peace with Humans. When M tried to examine the ill in order to discover what was afflicting them, the infected Morlocks turned into hideous monsters, which made M realize they were under the control of her brother, Emplate.
On the day of Evan's sixteenth birthday, his friends threw a party for him in what was left of Utopia, but Evan wasn't in mood for a party as he was upset, and decided to chill out somewhere else. Evan then went on a trip with Pickles, his destination being a small town on Kansas, a place that resembled the one that he grew on in his fake memories.
After returning Pickles to Hank's lab, Evan, out of curiosity, put the mask that Doctor Strange gave to Hank on. Meanwhile, Hank, who had been trying for weeks to discover a way to go back in time so he and his friends would return to their own world, did his last attempt of creating a time machine, which was unexpectedly sucessful. However, Hank and Evan were sent to Egypt some time about the eighteenth century BC, where they found themselves fighting the Sandstormers to save their lives. While Hank was incapacitated and heavily injured by their leader, Evan was rescued by none other than the younger version of En Sabah Nur, a.k.a. Apocalypse.